After you download the software, the setup is very simple: Double click the .exe file and follow the installation instructions. After installation you can launch Spybot by clicking on the Spybot icon (located on the desktop) or by clicking start > All Programs > Spybot Search and Destroy > Spybot S&D. The first thing you need to do after installing the program is to update it immediately by clicking on the Update button located on the left side, then click on Search for update, choose all the options, then click download. Preferably you should check for updates at least once a month. The program will not be as effective at removing spyware if not kept up to date.To scan your machine for spyware click on Search & Destroy located on the left side, then click check for problems located in the middle of the screen. It will take several minutes while your machine is being scanned for spyware. When the scan finishes, a list of possible spyware will be displayed. Check the box next to those problems you wish to fix. Then click on fixed selected problems. The program will then attempt to remove the files you have selected. Normally you can safely remove all of the files. It is possible some useful files might be listed. If you are not sure, please contact the help desk before removing. Occasionally, a popup window will tell you some spyware can't be removed. The tool will then ask you if you would like to run it when you start up your machine next time. Normally you should click yes. The reason some of the files cannot be removed is they were loaded into memory and are being used by some application. Click on the immunize button located on the left side to help block spyware in the future. For additional information on using Spybot, you can visit the support page.